Issue 23, 2011
From the journal:

Soft Matter

Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications†

Julio C. Cuggino,a   Cecilia I. Alvarez I.,a   Miriam C. Strumia,a   Pia Welker,b   Kai Licha,b   Dirk Steinhilber,c   Radu-Cristian Mutihacc  and  Marcelo Calderón*c  

* Corresponding authors

a IMBIV-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Edificio de Ciencias II, Ciudad Universitaria, Córdoba, Argentina

b mivenion GmbH, Robert-Koch-Platz 4, Berlin, Germany

c Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, Berlin, Germany
E-mail: calderonmarcelo@yahoo.es
Web: http://www.polytree.de
Fax: (+49) 30-838-53357

Abstract

In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.

Graphical abstract: Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications

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Article information

DOI
https://doi.org/10.1039/C1SM06357J
Article type
Paper
Submitted
19 Jul 2011
Accepted
23 Sep 2011
First published
17 Oct 2011

Soft Matter, 2011,7, 11259-11266

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Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications

J. C. Cuggino, C. I. Alvarez I., M. C. Strumia, P. Welker, K. Licha, D. Steinhilber, R. Mutihac and M. Calderón, Soft Matter, 2011, 7, 11259 DOI: 10.1039/C1SM06357J

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