Issue 18, 2011
From the journal:

Soft Matter

Self-assembled liposomes from amphiphilic electrospun nanofibers

Deng-Guang Yu,*a   Christopher Branford-White,*b   Gareth R. Williams,b   S. W. Annie Bligh,b   Kenneth White,b   Li-Min Zhu*c  and  Nicholas P. Chattertonb  

* Corresponding authors

a School of Material Science & Engineering, University of Shanghai for Science and Technology, Shanghai, China
E-mail: ydg017@gmail.com
Fax: +86(21) 55270632
Tel: +86(21) 55274069

b Institute for Health Research and Policy, Faculty of Life Sciences, London Metropolitan University, London, UK
E-mail: c.branfordwhite@londonmet.ac.uk

c College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China
E-mail: lzhu@dhu.edu.cn

Abstract

Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1–33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.

Graphical abstract: Self-assembled liposomes from amphiphilic electrospun nanofibers

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Article information

DOI
https://doi.org/10.1039/C1SM05961K
Article type
Paper
Submitted
24 May 2011
Accepted
29 Jun 2011
First published
03 Aug 2011

Soft Matter, 2011,7, 8239-8247

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Self-assembled liposomes from amphiphilic electrospun nanofibers

D. Yu, C. Branford-White, G. R. Williams, S. W. A. Bligh, K. White, L. Zhu and N. P. Chatterton, Soft Matter, 2011, 7, 8239 DOI: 10.1039/C1SM05961K

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