Issue 19, 2011
From the journal:

Soft Matter

Free energy analysis of vesicle-to-bicelle transformation†

Wataru Shinoda,*ab   Takenobu Nakamuraab  and  Steven O. Nielsenc  

* Corresponding authors

a Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 2, Umezono 1-1-1, Tsukuba, Japan
E-mail: w.shinoda@aist.go.jp
Fax: +81 29 851 5426
Tel: +81 29 861 6251

b CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, Japan

c Department of Chemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas, USA

Abstract

A lipid assembly composed of a finite number of lipid molecules can have multiple metastable structures. Using a series of coarse-grained molecular dynamics simulations, we evaluate the free energy profile for the transformation of a small vesicle to a disk-like structure called a bicelle. This free energy is found to be lower than that predicted from continuum elastic theory. For small unilamellar vesicles, the relaxation of the internal structure of the membrane is suggested to play an important role in lowering the free energy barrier for the vesicle-to-bicelle transformation.

Graphical abstract: Free energy analysis of vesicle-to-bicelle transformation

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Article information

DOI
https://doi.org/10.1039/C1SM05404J
Article type
Paper
Submitted
08 Mar 2011
Accepted
20 Jun 2011
First published
11 Aug 2011

Soft Matter, 2011,7, 9012-9020

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Free energy analysis of vesicle-to-bicelle transformation

W. Shinoda, T. Nakamura and S. O. Nielsen, Soft Matter, 2011, 7, 9012 DOI: 10.1039/C1SM05404J

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