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Issue 3, 2011
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Controlled drug release under a low frequency magnetic field: effect of the citrate coating on magnetoliposomes stability

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Abstract

The paper describes the effect of a low-frequency alternating magnetic field (LF-AMF) on the permeability and release properties of large (LUVs) and giant (GUVs) unilamellar vesicles loaded with citrate coated cobalt ferrite nanoparticles (NPs). The citrate shell allows a high loading of NPs in lipid vesicles without modifying their magnetic properties. The increase of magnetic LUVs permeability upon exposure to LF-AMF has been evaluated as the fluorescence self-quenching of carboxyfluorescein (CF) entrapped inside the liposome aqueous pool. Liposome leakage has been monitored as a function of field frequency, time exposure and concentration of the citrate coated NPs. Confocal Laser Scanning Microscopy (CLSM) experiments performed on magnetic GUVs labeled with the fluorescent probe DiIC18 and loaded with Alexa 488-C5-maleimide fluorescent dye provided insights on the release mechanism induced by LF-AMF. The results show that LF-AMF strongly affects vesicles permeability, suggesting the formation of pores in the lipid bilayer due to both hyperthermic effects and nanoparticle oscillations in the vesicles pool at the applied frequency. The behaviour of these magnetic vesicles in the presence of LF-AMF makes this system a good candidate for controlled drug delivery.

Graphical abstract: Controlled drug release under a low frequency magnetic field: effect of the citrate coating on magnetoliposomes stability

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Publication details

The article was received on 08 Aug 2010, accepted on 26 Oct 2010 and first published on 26 Nov 2010


Article type: Paper
DOI: 10.1039/C0SM00789G
Citation: Soft Matter, 2011,7, 1025-1037
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    Controlled drug release under a low frequency magnetic field: effect of the citrate coating on magnetoliposomes stability

    S. Nappini, M. Bonini, F. B. Bombelli, F. Pineider, C. Sangregorio, P. Baglioni and B. Nordèn, Soft Matter, 2011, 7, 1025
    DOI: 10.1039/C0SM00789G

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