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Issue 4, 2011
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DNA-programmed spatial screening of carbohydrate–lectin interactions

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Abstract

A wide range of multivalent scaffolds was assembled by using only five different PNA oligomers and various DNA templates. The flexibility of the PNA–DNA duplexes could be increased by introducing nick-sites and partially unpaired regions, as confirmed by MD simulations. The self-organized glyco-assemblies were used in a spatial screening of accessible carbohydrate binding sites in the Erythrina cristagalli lectin (ECL). This systematic investigation revealed a distance dependence which is in agreement with the crystal structure analysis.

Graphical abstract: DNA-programmed spatial screening of carbohydrate–lectin interactions

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Article information


Submitted
10 Nov 2010
Accepted
22 Dec 2010
First published
25 Jan 2011

Chem. Sci., 2011,2, 770-775
Article type
Edge Article

DNA-programmed spatial screening of carbohydrate–lectin interactions

C. Scheibe, A. Bujotzek, J. Dernedde, M. Weber and O. Seitz, Chem. Sci., 2011, 2, 770
DOI: 10.1039/C0SC00565G

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