Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 7, 2011
Previous Article Next Article

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

Author affiliations

Abstract

New pleuromutilin-like compounds were synthesized in approximately 11 steps from 3-allylcyclopent-2-enone by a strategy featuring sequential carbonyl addition reactions. Several analogs possessing the C14 tiamulin ester side chain displayed activity in a Mycobacterium tuberculosis mc27000 assay. The results described herein provide a basis for further efforts to expand the structural and stereochemical diversity of the pleuromutilin class of bacterial protein synthesis inhibitors through advances in chemical synthesis.

Graphical abstract: Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

Back to tab navigation

Supplementary files

Article information


Submitted
28 Feb 2011
Accepted
22 Mar 2011
First published
14 Apr 2011

Chem. Sci., 2011,2, 1258-1261
Article type
Edge Article

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

S. D. Lotesta, J. Liu, E. V. Yates, I. Krieger, J. C. Sacchettini, J. S. Freundlich and E. J. Sorensen, Chem. Sci., 2011, 2, 1258
DOI: 10.1039/C1SC00116G

Social activity

Search articles by author

Spotlight

Advertisements