Issue 7, 2011

Metal-mediated fabrication of new functional G-quartet-based supramolecular nanostructure and potential application as controlled drug release system

Abstract

The creation and expansion of addressable supramolecular architectures in a facile and economic way with further functions still remain a big challenge in the field of self-assembly. Herein, we demonstrated a novel strategy to construct a metal-mediated G-quartet-based supramolecular nanostructure with controllable functions. By using 5′-GMP as basic building blocks in dilute solution, the Sr2+ promoted assemblies are simple and intuitive, yet cost-effective. The resulting structures can be regarded as completely homogeneous from the structural point of view and the nanowires are much longer than those previously reported. The nanowires can be controlled by chemical input signals, namely, divalent metal ions and a chelating agent. Furthermore, the encapsulating feature of this system towards G-quadruplex-specific ligands might be of particular biological significance, in the framework of nucleic telomerase.

Graphical abstract: Metal-mediated fabrication of new functional G-quartet-based supramolecular nanostructure and potential application as controlled drug release system

Supplementary files

Article information

Article type
Edge Article
Submitted
24 Feb 2011
Accepted
09 Apr 2011
First published
12 May 2011

Chem. Sci., 2011,2, 1356-1361

Metal-mediated fabrication of new functional G-quartet-based supramolecular nanostructure and potential application as controlled drug release system

D. Hu, J. Ren and X. Qu, Chem. Sci., 2011, 2, 1356 DOI: 10.1039/C1SC00109D

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