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Issue 2, 2011
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Amine directed Pd(ii)-catalyzed C–H bond functionalization under ambient conditions

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Abstract

Pd(II)-catalyzed C–H bond functionalizations that proceed under ambient conditions are a pivotal part of the future of chemical synthesis. Herein, an amine directed Pd(II)-catalyzed C–H bond functionalization strategy is described that generates a diversity of molecular frameworks via C–H carbonylation, C–H arylation and C–H amination. The new reactions work for a variety of substrates and are tolerant of delicate stereogenic centres and functionality. Furthermore, the new reactions can be sequenced to generate complex architectures from simple building blocks via iterative Pd(II)-catalyzed C–H bond functionalization.

Graphical abstract: Amine directed Pd(ii)-catalyzed C–H bond functionalization under ambient conditions

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Supplementary files

Article information


Submitted
10 Jul 2010
Accepted
24 Sep 2010
First published
15 Oct 2010

Chem. Sci., 2011,2, 312-315
Article type
Edge Article

Amine directed Pd(II)-catalyzed C–H bond functionalization under ambient conditions

B. Haffemayer, M. Gulias and M. J. Gaunt, Chem. Sci., 2011, 2, 312
DOI: 10.1039/C0SC00367K

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