Jump to main content
Jump to site search

Issue 8, 2011
Previous Article Next Article

Fluorinated contrast agents for magnetic resonance imaging; a review of recent developments

Author affiliations

Abstract

The development of medical imaging probes for magnetic resonance imaging (MRI) is a particularly dynamic area of research. At present, many prominent groups are dedicating significant resources to tailoring and optimising the performance of potential contrast agents. Whilst 1H MRI has become an indispensable tool for the imaging of disease states, it frequently suffers from low contrast owing to background signal from intrinsic 1H. As a result, increasing attention is being directed at compounds containing 19F as this nucleus has a similar NMR sensitivity to 1H and, importantly, intrinsic 19F signals are virtually undetectable in vivo. For several decades, perfluorinated molecules (in which all of the C–H bonds in the parent molecule have been replaced with C–F bonds) and highly fluorous gases such as SF6 have traditionally been used for these kinds of investigations and there have been some excellent reviews of these compounds and their applications. However, recently 19F imaging is showing signs of evolution, particularly as there have been several reports of fluorinated responsive (smart) agents, micelles, dendrimers and hyperbranched polymers being investigated as targets for 19F-MRI. Furthermore, examples of multimodal contrast agents containing 19F nuclei are also starting to emerge. In this review we aim to summarise these exciting recent chemical developments.

Graphical abstract: Fluorinated contrast agents for magnetic resonance imaging; a review of recent developments

Back to tab navigation

Article information


Submitted
22 Aug 2011
Accepted
20 Sep 2011
First published
26 Oct 2011

RSC Adv., 2011,1, 1415-1425
Article type
Review Article

Fluorinated contrast agents for magnetic resonance imaging; a review of recent developments

J. C. Knight, P. G. Edwards and S. J. Paisey, RSC Adv., 2011, 1, 1415
DOI: 10.1039/C1RA00627D

Social activity

Search articles by author

Spotlight

Advertisements