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Issue 10, 2011
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Atorvastatin and clopidogrel interfere with photosensitization in vitro

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Abstract

Photodynamic therapy (PDT) has been used to eliminate undesired cells by using a combination of photosensitizers and light illumination to generate reactive oxygen species. There is great interest in applying PDT to atherosclerosis; preferential destruction of pro-inflammatory macrophages in atheromata might attenuate plaque growth or rupture-prone vulnerability. Here, we report on a previously unknown interaction between cardiovascular drugs that are commonly prescribed for atherosclerosis patients and the cytolytic effects of photodynamic therapy using Cathepsin B activatable photosensitizer L-SR15 on murine macrophage Raw 264.7 cells in culture. Atorvastatin and clopidogrel significantly interfered with in vitro photosensitization effect while aspirin did this to a lesser extent; these drugs did not change the efficiency of cellular uptake of L-SR15 after in vitro photosensitization. A photosensitization interference effect of atorvastatin and clopidogrel was also observed when using a conventional photosensitizer free Ce6 or NCI-H1299 cancer cells. Considering the clinical implications of PDT, our study merits further investigation in clinical settings as well as in animal models.

Graphical abstract: Atorvastatin and clopidogrel interfere with photosensitization in vitro

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Publication details

The article was received on 01 Dec 2010, accepted on 04 Jun 2011 and first published on 12 Jul 2011


Article type: Paper
DOI: 10.1039/C0PP00363H
Photochem. Photobiol. Sci., 2011,10, 1587-1592

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    Atorvastatin and clopidogrel interfere with photosensitization in vitro

    D. K. Lee, Y. Choi, S. Shon, D. Schellingerhout, J. E. Park and D. Kim, Photochem. Photobiol. Sci., 2011, 10, 1587
    DOI: 10.1039/C0PP00363H

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