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Issue 1, 2011
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Multiple prototropism of fisetin in sodium cholate and related bile salt media

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Abstract

Fisetin, a bioflavonoid, has important biological relevance. It exhibits intramolecular excited state proton transfer (ESIPT), analogous to the structurally similar flavonoids. The presence of multiple prototropic forms of fisetin was observed at various concentrations of different bile salt molecules. The presence of ground state fisetin anion (FA)GS (λex 418 nm; λem 490 nm) in alcohols and bile salt micellar media is a novel observation. The interaction of fisetin with sodium cholate (NaC) and some other bile salts has been studied in detail, using the intrinsic fluorescence of different prototropic forms of fisetin: neutral form (FN, λex 369 nm, λem ∼ 400 nm), ground state anion form ((FA)GS, λex 418 nm, λem 490 nm) and phototautomer (FT, λex 369 nm, λem 540 nm). The hypsochromic shift of (FA*)ES emission and bathochromic shift of FT emission with increasing bile salt concentration suggests the progressive reduction of polarity of the bile salt media, which could be resulting from the neutralization of bile salt molecules as their concentration increases.

Graphical abstract: Multiple prototropism of fisetin in sodium cholate and related bile salt media

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Publication details

The article was received on 25 May 2010, accepted on 27 Sep 2010 and first published on 26 Oct 2010


Article type: Paper
DOI: 10.1039/C0PP00120A
Citation: Photochem. Photobiol. Sci., 2011,10, 66-75
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    Multiple prototropism of fisetin in sodium cholate and related bile salt media

    S. Selvam and A. K. Mishra, Photochem. Photobiol. Sci., 2011, 10, 66
    DOI: 10.1039/C0PP00120A

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