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Issue 19, 2011
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Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

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Abstract

A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.

Graphical abstract: Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

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Publication details

The article was received on 01 Jun 2011, accepted on 11 Jul 2011 and first published on 12 Aug 2011


Article type: Paper
DOI: 10.1039/C1OB05870C
Citation: Org. Biomol. Chem., 2011,9, 6844-6850
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    Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

    M. Rueping, T. Theissmann, M. Stoeckel and A. P. Antonchick, Org. Biomol. Chem., 2011, 9, 6844
    DOI: 10.1039/C1OB05870C

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