Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by 1H STD NMR techniques

David M. Dias; João M. C. Teixeira; Ilya Kuprov; Elizabeth J. New; David Parker; Carlos F. G. C. Geraldes

doi:10.1039/C1OB05524K

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Enantioselective binding of a lanthanide(iii) complex to human serum albumin studied by ¹H STD NMR techniques†

David M. Dias,^a João M. C. Teixeira,^a Ilya Kuprov,^b Elizabeth J. New,^b David Parker^b and Carlos F. G. C. Geraldes*^a

Author affiliations

* Corresponding authors

^a Department of Life Sciences and Center of Neurosciences and Cell Biology, Faculty of Science and Technology, University of Coimbra, P.O. Box 3046, 3001-401 Coimbra, Portugal
E-mail: geraldes@bioq.uc.pt

^b Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: david.parker@durham.ac.uk

Abstract

The enantioselective binding of the (SSS)-Δ isomer of an yttrium(III) tetraazatriphenylene complex to ‘drug-site II’ of human serum albumin (HSA) was detected by the intensity differences of its STD ¹H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.

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Article information

DOI: https://doi.org/10.1039/C1OB05524K
Article type: Communication
Submitted: 04 Apr 2011
Accepted: 17 May 2011
First published: 18 May 2011

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Org. Biomol. Chem., 2011,9, 5047-5050

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Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by ¹H STD NMR techniques

D. M. Dias, J. M. C. Teixeira, I. Kuprov, E. J. New, D. Parker and C. F. G. C. Geraldes, Org. Biomol. Chem., 2011, 9, 5047 DOI: 10.1039/C1OB05524K

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Organic & Biomolecular Chemistry