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Issue 13, 2011
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Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

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Abstract

We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.

Graphical abstract: Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

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Publication details

The article was received on 04 Apr 2011, accepted on 12 May 2011 and first published on 12 May 2011


Article type: Communication
DOI: 10.1039/C1OB05519D
Org. Biomol. Chem., 2011,9, 4760-4762

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    Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

    M. Vendrell, A. Samanta, S. Yun and Y. Chang, Org. Biomol. Chem., 2011, 9, 4760
    DOI: 10.1039/C1OB05519D

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