Issue 13, 2011

Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Abstract

We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.

Graphical abstract: Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
04 Apr 2011
Accepted
12 May 2011
First published
12 May 2011

Org. Biomol. Chem., 2011,9, 4760-4762

Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

M. Vendrell, A. Samanta, S. Yun and Y. Chang, Org. Biomol. Chem., 2011, 9, 4760 DOI: 10.1039/C1OB05519D

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