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Issue 9, 2011

Novel one-pot process for the synthesis of 1,3-thiazolesvia organocatalysed epoxidation of nitro-olefins

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Abstract

A facile one-pot two-step process for the synthesis of 1,3-thiazole heterocycles via organocatalytic epoxidation of nitro-olefins with the t-BuOOH/DBU system, and subsequent reaction of α-nitro-epoxides with thioamides under mild conditions has been developed.

Graphical abstract: Novel one-pot process for the synthesis of 1,3-thiazolesvia organocatalysed epoxidation of nitro-olefins

Supplementary files

Article information


Submitted
02 Jan 2011
Accepted
23 Feb 2011
First published
23 Mar 2011

Org. Biomol. Chem., 2011,9, 3457-3461
Article type
Paper

Novel one-pot process for the synthesis of 1,3-thiazolesvia organocatalysed epoxidation of nitro-olefins

K. M. Weiß, S. Wei and S. B. Tsogoeva, Org. Biomol. Chem., 2011, 9, 3457 DOI: 10.1039/C1OB05260H

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