Jump to main content
Jump to site search

Issue 8, 2011
Previous Article Next Article

Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives

Author affiliations

Abstract

Four new di-substituted phenanthroline-based compounds a–d have been designed and prepared, and they have been shown to induce the formation of anti-parallel structure of human telomeric G-quadruplex DNA by CD spectra. FRET assay indicates that the melting temperature increases (ΔTm values) of G-quadruplex in buffer (pH 7.4) containing 100 mM NaCl are 31.6, 34.6, 17.8 and 32.6 °C for the compounds (1.0 μM) a, b, c and d, respectively. Competitive FRET assay shows that the four compounds exhibit a high G-quadruplex DNA selectivity over duplex DNA. Three of the compounds are the potent telomerase inhibitors and HeLa cell proliferation inhibitors.

Graphical abstract: Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Nov 2010, accepted on 12 Jan 2011 and first published on 12 Jan 2011


Article type: Paper
DOI: 10.1039/C0OB00961J
Citation: Org. Biomol. Chem., 2011,9, 2648-2653
  •   Request permissions

    Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives

    L. Wang, Y. Wen, J. Liu, J. Zhou, C. Li and C. Wei, Org. Biomol. Chem., 2011, 9, 2648
    DOI: 10.1039/C0OB00961J

Search articles by author

Spotlight

Advertisements