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Issue 10, 2011
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Preparation of fluoxetine by multiple flow processing steps

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Abstract

Microflow technology is established as a modern and fashionable tool in synthetic organic chemistry, bringing great improvement and potential, on account of a series of advantages over flask methods. The study presented here focuses on the application of flow chemistry process in performing an efficient multiple step syntheses of (±)-fluoxetine as an alternative to conventional synthetic methods, and one of the few examples of total synthesis accomplished by flow technique.

Graphical abstract: Preparation of fluoxetine by multiple flow processing steps

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Article information


Submitted
20 Oct 2010
Accepted
16 Dec 2010
First published
30 Mar 2011

Org. Biomol. Chem., 2011,9, 3854-3862
Article type
Paper

Preparation of fluoxetine by multiple flow processing steps

B. Ahmed-Omer and A. J. Sanderson, Org. Biomol. Chem., 2011, 9, 3854
DOI: 10.1039/C0OB00906G

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