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Issue 6, 2011
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A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

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Abstract

Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.

Graphical abstract: A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

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Publication details

The article was received on 01 Oct 2010, accepted on 22 Nov 2010 and first published on 31 Jan 2011


Article type: Paper
DOI: 10.1039/C0OB00815J
Org. Biomol. Chem., 2011,9, 1938-1947

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    A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

    C. J. Smith, N. Nikbin, S. V. Ley, H. Lange and I. R. Baxendale, Org. Biomol. Chem., 2011, 9, 1938
    DOI: 10.1039/C0OB00815J

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