Issue 24, 2011
From the journal:

Organic & Biomolecular Chemistry

Construction of a tunable metallohydrolase center on an invertible molecular pocket†

Zhiming Zhang,ac   Junqiu Liu,*a   Quan Luo,a   Jiawei Zhang,b   Jiayun Xua  and  X. X. Zhu*b  

* Corresponding authors

a State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, China
E-mail: junqiuliu@jlu.edu.cn
Fax: +86-431-85193421

b Département de Chimie, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montréal, QC, Canada
E-mail: julian.zhu@umontreal.ca

c Hebei Province Key Laboratory of Inorganic Nonmetallic Materials, College of Materials Science and Engineering, Hebei United University, Tangshan, China

Abstract

A trimer of cholic acid made by linking three cholic acid molecules with pentaerythritolvia click chemistry serves as the center of an artificial metallohydrolase after the complexation of the triazole groups with a Zn2+ ion. The invertible amphiphilic cavity can respond to the change in polarity of the solvent media and efficiently modulate the catalytic activity of the artificial enzyme.

Graphical abstract: Construction of a tunable metallohydrolase center on an invertible molecular pocket

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Article information

DOI
https://doi.org/10.1039/C1OB06174G
Article type
Communication
Submitted
15 Jul 2011
Accepted
19 Sep 2011
First published
19 Sep 2011

Org. Biomol. Chem., 2011,9, 8220-8223

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Construction of a tunable metallohydrolase center on an invertible molecular pocket

Z. Zhang, J. Liu, Q. Luo, J. Zhang, J. Xu and X. X. Zhu, Org. Biomol. Chem., 2011, 9, 8220 DOI: 10.1039/C1OB06174G

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