Issue 21, 2011

A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles

Abstract

A one-pot two-step microwave assisted synthesis of variously disubstituted 1,2,4-oxadiazoles from carboxylic acids and amidoximes is reported. This methodology is characterized by short reaction times, is versatile, robust and high-yielding and allows for the preparation of heterocycles with a stereocenter with 100% enantiomeric purity.

Graphical abstract: A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles

Supplementary files

Article information

Article type
Paper
Submitted
30 Jun 2011
Accepted
10 Aug 2011
First published
11 Aug 2011

Org. Biomol. Chem., 2011,9, 7539-7546

A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles

A. Porcheddu, R. Cadoni and L. De Luca, Org. Biomol. Chem., 2011, 9, 7539 DOI: 10.1039/C1OB06055D

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