Issue 21, 2011
From the journal:

Organic & Biomolecular Chemistry

Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes†

Marie-Pierre Maether,a   Virginie Bernat,a   Marie Maturano,a   Christiane André-Barrès,a   Sonia Ladeira,b   Alexis Valentin,c   Henri Viald  and  Corinne Payrastre*a  

* Corresponding authors

a Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (UMR 5068), Université de Toulouse (Université Paul Sabatier), 31062 Toulouse Cedex 9, France
E-mail: payrastr@chimie.ups-tlse.fr
Fax: (+)330561556011
Tel: (+)330561558392

b Université de Toulouse, UPS, Structure Fédérative Toulousaine en Chimie Moléculaire, FR2599, 118 Route de Narbonne, F-31062 Toulouse, France

c UPS and IRD, Pharma-DEV, UMR 152, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse cedex 9, France

d Dynamique des Interactions Membranaires Normales et Pathologiques (UMR 5235), Université Montpellier; 2, cc 107, Place E. Bataillon, 34095 Montpellier cedex 5, France

Abstract

Two series of streptocyanine dyes incorporating cyclic peroxide or 4-aminoquinoline moieties are prepared and X-ray diffraction structures for three compounds are determined. All hybrid dyes show good antiplasmodial activity (0.06 to 0.66 μM) and are not or are slightly cytotoxic, except 10a.

Graphical abstract: Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes

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Article information

DOI
https://doi.org/10.1039/C1OB06048A
Article type
Paper
Submitted
29 Jun 2011
Accepted
21 Jul 2011
First published
25 Jul 2011

Org. Biomol. Chem., 2011,9, 7400-7410

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Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes

M. Maether, V. Bernat, M. Maturano, C. André-Barrès, S. Ladeira, A. Valentin, H. Vial and C. Payrastre, Org. Biomol. Chem., 2011, 9, 7400 DOI: 10.1039/C1OB06048A

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