Issue 20, 2011
From the journal:

Organic & Biomolecular Chemistry

An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(i)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile†

Xingxin Yu,a   Qin Yang,b   Honglei Lou,a   Yiyuan Peng*b  and  Jie Wu*a  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, China
E-mail: jie_wu@fudan.edu.cn
Fax: 86 21 6564 1740
Tel: 86 21 6510 2412

b Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi, China

Abstract

A three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile catalyzed by silver triflate under mild conditions is reported, which generates pyrazolo[5,1-a]isoquinolin-2-amines in good to excellent yields.

Graphical abstract: An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(i)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile

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Article information

DOI
https://doi.org/10.1039/C1OB05917C
Article type
Paper
Submitted
08 Jun 2011
Accepted
27 Jun 2011
First published
03 Aug 2011

Org. Biomol. Chem., 2011,9, 7033-7037

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An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile

X. Yu, Q. Yang, H. Lou, Y. Peng and J. Wu, Org. Biomol. Chem., 2011, 9, 7033 DOI: 10.1039/C1OB05917C

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