Issue 19, 2011
From the journal:

Organic & Biomolecular Chemistry

Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids

Yong-Chul Jeong,a   Muhammad Anwar,a   Tuan Minh Nguyen,b   Benjamin Song Wei Tan,ab   Christina Li Lin Chai*bc  and  Mark G. Moloney*a  

* Corresponding authors

a Chemistry Research Laboratory, University of Oxford, Mansfield Rd, University of Oxford, Oxford, U.K
E-mail: mark.moloney@chem.ox.ac.uk
Tel: +44 1865 275656

b Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, Neuros, #07-01, Singapore

c Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore
E-mail: christina_chai@ices.a-star.edu.sg
Tel: +65 6799-8522

Abstract

An efficient strategy for the control of the chemoselectivity in Dieckmann ring closures leading to tetramic acids derived from serine and α-methyl serine is reported, and this provides pathways to diversely substituted systems from a common starting material.

Graphical abstract: Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids

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Article information

DOI
https://doi.org/10.1039/C1OB05816A
Article type
Paper
Submitted
24 May 2011
Accepted
20 Jun 2011
First published
20 Jun 2011

Org. Biomol. Chem., 2011,9, 6663-6669

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Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids

Y. Jeong, M. Anwar, T. M. Nguyen, B. S. W. Tan, C. L. L. Chai and M. G. Moloney, Org. Biomol. Chem., 2011, 9, 6663 DOI: 10.1039/C1OB05816A

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