Issue 16, 2011

Biomimetic peptide bond formation in water with aminoacyl phosphate esters

Abstract

Aminoacyl phosphates, biomimetic analogues of aminoacyl adenylates, react efficiently with amino acid esters to form dipeptides with retention of stereochemical integrity. The reactions are selective and occur readily in the presence of nucleophiles other than amino groups on their side chains. Aminoacyl phosphate esters that lack an amino-protecting group are also suitable for peptide bond formation, leading to a simplified overall process.

Graphical abstract: Biomimetic peptide bond formation in water with aminoacyl phosphate esters

Supplementary files

Article information

Article type
Communication
Submitted
27 Apr 2011
Accepted
21 Jun 2011
First published
21 Jun 2011

Org. Biomol. Chem., 2011,9, 5645-5647

Biomimetic peptide bond formation in water with aminoacyl phosphate esters

R. S. Dhiman, L. G. Opinska and R. Kluger, Org. Biomol. Chem., 2011, 9, 5645 DOI: 10.1039/C1OB05660C

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