Issue 16, 2011
From the journal:

Organic & Biomolecular Chemistry

Cobalt(ii)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphineligands in air†

Feng Yu,a   Xi-Chang Zhang,ab   Fei-Fei Wu,a   Ji-Ning Zhou,a   Wenjun Fang,b   Jing Wu*a  and  Albert S. C. Chan*c  

* Corresponding authors

a College of Material, Chemistry and Chemical Engineering and Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310036, China
E-mail: jingwubc@hznu.edu.cn
Fax: (+86)-571-2886-8023

b Department of Chemistry, Zhejiang University, Hangzhou 310027, China

c State Key Laboratory of Chiroscience and Institute of Creativity, Hong Kong Baptist University, Hong Kong
E-mail: ascchan@hkbu.edu.hk
Fax: (+852)-3411-2123

Abstract

In the presence of PhSiH3 as the hydride donor, catalytic amounts of non-racemic dipyridylphosphine and an easy-to-handle cobalt salt Co(OAc)2ยท4H2O formed in situ an effective catalyst system for the asymmetric reduction of a diverse range of aryl alkyl ketones with moderate-to-excellent enantioselectivities (up to 96% ee). This approach tolerated the handling of both catalyst and reactants under air without special precautions.

Graphical abstract: Cobalt(ii)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air

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Article information

DOI
https://doi.org/10.1039/C1OB05494E
Article type
Communication
Submitted
29 Mar 2011
Accepted
14 Jun 2011
First published
14 Jun 2011

Org. Biomol. Chem., 2011,9, 5652-5654

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Cobalt(II)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air

F. Yu, X. Zhang, F. Wu, J. Zhou, W. Fang, J. Wu and A. S. C. Chan, Org. Biomol. Chem., 2011, 9, 5652 DOI: 10.1039/C1OB05494E

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