Issue 24, 2011
From the journal:

Organic & Biomolecular Chemistry

Pyridoxine-derived bicyclic aminopyridinolantioxidants: synthesis and their antioxidant activities†

Tae-gyu Nam,ab   Jin-Mo Ku,c   Christopher L. Rector,a   Hoyoung Choi,d   Ned A. Porter*a  and  Byeong-Seon Jeong*d  

* Corresponding authors

a Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA
E-mail: n.porter@vanderbilt.edu
Fax: +1-615-343-5478
Tel: +1-615-343-2693

b College of Pharmacy, Hanyang University, Ansan, Republic of Korea

c Gyeonggi Bio-Center, Suwon, Republic of Korea

d College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea
E-mail: jeongb@ynu.ac.kr
Fax: +82-53-810-4654
Tel: +82-53-810-2814

Abstract

A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.

Graphical abstract: Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1OB05144J
Article type
Paper
Submitted
27 Jan 2011
Accepted
22 Sep 2011
First published
22 Sep 2011

Org. Biomol. Chem., 2011,9, 8475-8482

Permissions

Request permissions

Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities

T. Nam, J. Ku, C. L. Rector, H. Choi, N. A. Porter and B. Jeong, Org. Biomol. Chem., 2011, 9, 8475 DOI: 10.1039/C1OB05144J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements