Jump to main content
Jump to site search

Issue 8, 2011
Previous Article Next Article

Release of bioactive volatiles from supramolecular hydrogels: influence of reversible acylhydrazone formation on gel stability and volatile compound evaporation

Author affiliations

Abstract

In the presence of alkali metal cations, guanosine-5′-hydrazide (1) forms stable supramolecular hydrogels by selective self-assembly into a G-quartet structure. Besides being physically trapped inside the gel structure, biologically active aldehydes or ketones can also reversibly react with the free hydrazide functions at the periphery of the G-quartet to form acylhydrazones. This particularity makes the hydrogels interesting as delivery systems for the slow release of bioactive carbonyl derivatives. Hydrogels formed from 1 were found to be significantly more stable than those obtained from guanosine. Both physical inclusion of bioactive volatiles and reversible hydrazone formation could be demonstrated by indirect methods. Gel stabilities were measured by oscillating disk rheology measurements, which showed that thermodynamic equilibration of the gel is slow and requires several cooling and heating cycles. Furthermore, combining the rheology data with dynamic headspace analysis of fragrance evaporation suggested that reversible hydrazone formation of some carbonyl compounds influences the release of volatiles, whereas the absolute stability of the gel seemed to have no influence on the evaporation rates.

Graphical abstract: Release of bioactive volatiles from supramolecular hydrogels: influence of reversible acylhydrazone formation on gel stability and volatile compound evaporation

Back to tab navigation

Supplementary files

Article information


Submitted
08 Dec 2010
Accepted
01 Feb 2011
First published
07 Mar 2011

Org. Biomol. Chem., 2011,9, 2906-2919
Article type
Paper

Release of bioactive volatiles from supramolecular hydrogels: influence of reversible acylhydrazone formation on gel stability and volatile compound evaporation

B. Buchs (née Levrand), W. Fieber, F. Vigouroux-Elie, N. Sreenivasachary, J. Lehn and A. Herrmann, Org. Biomol. Chem., 2011, 9, 2906
DOI: 10.1039/C0OB01139H

Social activity

Search articles by author

Spotlight

Advertisements