First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

Chia-Lin Lee; Chi-Huan Huang; Hui-Chun Wang; Da-Wei Chuang; Ming-Jung Wu; Sheng-Yang Wang; Tsong-Long Hwang; Chin-Chung Wu; Yeh-Long Chen; Fang-Rong Chang; Yang-Chang Wu

doi:10.1039/C0OB00616E

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents†

Chia-Lin Lee,^ah Chi-Huan Huang,‡^a Hui-Chun Wang,^a Da-Wei Chuang,^a Ming-Jung Wu,^b Sheng-Yang Wang,^c Tsong-Long Hwang,^d Chin-Chung Wu,^a Yeh-Long Chen,^e Fang-Rong Chang*^af and Yang-Chang Wu*^agh

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^a Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
E-mail: aaronfrc@kmu.edu.tw
Fax: +886 7 311 4773
Tel: +886 7 312 1101 ext. 2162

^b Department of Chemistry, National Sun Yant-sen University, Kaohsiung 804, Taiwan

^c Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan

^d Graduate Institute of Natural Products, Chang Gung University, Tao-Yuan 333, Taiwan

^e Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan

^f Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

^g Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
E-mail: yachwu@mail.cmu.edu.tw
Fax: +886 4 220 60248
Tel: +886 4 220 57153

^h Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 40402, Taiwan

Abstract

Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

Organic & Biomolecular Chemistry

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents†

Abstract

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First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

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