Issue 5, 2011

A facile process for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone enolates to sulfinylimine

Abstract

An efficient method for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone-derivative enolates to trifluoromethylated sulfinylimine has been developed, with good chemical yields and excellent diastereoselectivities. This practical method was also proved to be suitable for large-scale preparation.

Graphical abstract: A facile process for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone enolates to sulfinylimine

Supplementary files

Article information

Article type
Paper
Submitted
16 Aug 2010
Accepted
11 Nov 2010
First published
05 Jan 2011

Org. Biomol. Chem., 2011,9, 1402-1406

A facile process for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone enolates to sulfinylimine

H. Mei, Y. Xiong, J. Han and Y. Pan, Org. Biomol. Chem., 2011, 9, 1402 DOI: 10.1039/C0OB00586J

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