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Issue 10, 2011
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Macromolecular nanotheranostics for multimodal anticancer therapy

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Abstract

Macromolecular carrier materials based on N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized drug delivery systems that have been extensively evaluated in the past two decades, both at the preclinical and at the clinical level. Using several different imaging agents and techniques, HPMA copolymers have been shown to circulate for prolonged periods of time, and to accumulate in tumors both effectively and selectively by means of the Enhanced Permeability and Retention (EPR) effect. Because of this, HPMA-based macromolecular nanotheranostics, i.e. formulations containing both drug and imaging agents within a single formulation, have been shown to be highly effective in inducing tumor growth inhibition in animal models. In patients, however, as essentially all other tumor-targeted nanomedicines, they are generally only able to improve the therapeutic index of the attached active agent by lowering its toxicity, and they fail to improve the efficacy of the intervention. Bearing this in mind, we have recently reasoned that because of their biocompatibility and their beneficial biodistribution, nanomedicine formulations might be highly suitable systems for combination therapies. In the present manuscript, we briefly summarize several exemplary efforts undertaken in this regard in our labs in the past couple of years, and we show that long-circulating and passively tumor-targeted macromolecular nanotheranostics can be used to improve the efficacy of radiochemotherapy and of chemotherapy combinations.

Graphical abstract: Macromolecular nanotheranostics for multimodal anticancer therapy

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Publication details

The article was received on 05 Jul 2011, accepted on 12 Aug 2011 and first published on 08 Sep 2011


Article type: Feature Article
DOI: 10.1039/C1NR10733J
Citation: Nanoscale, 2011,3, 4022-4034
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    Macromolecular nanotheranostics for multimodal anticancer therapy

    R. Huis in 't Veld, G. Storm, W. E. Hennink, F. Kiessling and T. Lammers, Nanoscale, 2011, 3, 4022
    DOI: 10.1039/C1NR10733J

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