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Issue 8, 2011
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Engineered nanoparticles for biomolecular imaging

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In recent years, the production of nanoparticles (NPs) and exploration of their unusual properties have attracted the attention of physicists, chemists, biologists and engineers. Interest in NPs arises from the fact that the mechanical, chemical, electrical, optical, magnetic, electro-optical and magneto-optical properties of these particles are different from their bulk properties and depend on the particle size. There are numerous areas where nanoparticulate systems are of scientific and technological interest, particularly in biomedicine where the emergence of NPs with specific properties (e.g. magnetic and fluorescence) for contrast agents can lead to advancing the understanding of biological processes at the biomolecular level. This review will cover a full description of the physics of various imaging methods, including MRI, optical techniques, X-rays and CT. In addition, the effect of NPs on the improvement of the mentioned non-invasive imaging methods will be discussed together with their advantages and disadvantages. A detailed discussion will also be provided on the recent advances in imaging agents, such as fluorescent dye-doped silica NPs, quantum dots, gold- and engineered polymeric-NPs, superparamagnetic iron oxide NPs (SPIONs), and multimodal NPs (i.e. nanomaterials that are active in both MRI and optical methods), which are employed to overcome many of the limitations of conventional contrast agents (e.g. gadolinium).

Graphical abstract: Engineered nanoparticles for biomolecular imaging

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The article was received on 28 Mar 2011, accepted on 28 Apr 2011 and first published on 29 Jun 2011

Article type: Review Article
DOI: 10.1039/C1NR10326A
Citation: Nanoscale, 2011,3, 3007-3026
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    Engineered nanoparticles for biomolecular imaging

    M. Mahmoudi, V. Serpooshan and S. Laurent, Nanoscale, 2011, 3, 3007
    DOI: 10.1039/C1NR10326A

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