Issue 12, 2011
From the journal:

Nanoscale

Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI†

Ruijun Xing,ab   Fan Zhang,a   Jin Xie,a   Maria Aronova,c   Guofeng Zhang,c   Ning Guo,a   Xinglu Huang,a   Xiaolian Sun,d   Gang Liu,a   L. Henry Bryant,e   Ashwinkumar Bhirde,b   Amy Liang,a   Yanglong Hou,b   Richard D. Leapman,c   Shouheng Sund  and  Xiaoyuan Chen*a  

* Corresponding authors

a Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering(NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA
E-mail: shawn.chen@nih.gov

b Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, P.R. China

c Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering(NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA

d Department of Chemistry, Brown University, Providence, RI, USA

e Laboratory of Diagnostic Radiology Research (CC), National Institutes of Health (NIH), Bethesda, MD, USA

Abstract

We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.

Graphical abstract: Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI

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Article information

DOI
https://doi.org/10.1039/C1NR11242B
Article type
Communication
Submitted
04 Sep 2011
Accepted
11 Oct 2011
First published
07 Nov 2011

Nanoscale, 2011,3, 4943-4945

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Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI

R. Xing, F. Zhang, J. Xie, M. Aronova, G. Zhang, N. Guo, X. Huang, X. Sun, G. Liu, L. H. Bryant, A. Bhirde, A. Liang, Y. Hou, R. D. Leapman, S. Sun and X. Chen, Nanoscale, 2011, 3, 4943 DOI: 10.1039/C1NR11242B

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