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Issue 2, 2011
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Biocompatible glutathione capped gold clusters as one- and two-photon excitation fluorescence contrast agents for live cells imaging

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Abstract

The one- and two-photon excitation emission properties of water soluble glutathione monolayer protected gold clusters were investigated. Strong two-photon emission was observed from the gold clusters. The two-photon absorption cross section of these gold clusters in water was deduced from the z-scan measurement to be 189 740 GM, which is much higher compared to organic fluorescent dyes and quantum dots. These gold clusters also showed high photo-stability. The MTT assay showed that these gold clusters have low toxicity even at high concentrations. We have successfully demonstrated their applications for both one and two-photon excitation live cell imaging. The exceptional properties of these gold clusters make them a promising alternative for one- and two-photon bio-imaging and other nonlinear optical applications.

Graphical abstract: Biocompatible glutathione capped gold clusters as one- and two-photon excitation fluorescence contrast agents for live cells imaging

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Publication details

The article was received on 01 Jul 2010, accepted on 12 Aug 2010 and first published on 13 Oct 2010


Article type: Paper
DOI: 10.1039/C0NR00458H
Citation: Nanoscale, 2011,3, 429-434
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    Biocompatible glutathione capped gold clusters as one- and two-photon excitation fluorescence contrast agents for live cells imaging

    L. Polavarapu, M. Manna and Q. Xu, Nanoscale, 2011, 3, 429
    DOI: 10.1039/C0NR00458H

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