Issue 3, 2011
From the journal:

Nanoscale

Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs†

Antonello Di Crescenzo,a   Diana Velluto,b   Jeffrey A. Hubbellb  and  Antonella Fontana*a  

* Corresponding authors

a Dipartimento di Scienze del Farmaco, Università “G. d'Annunzio”, Via dei Vestini, Chieti, Italy
E-mail: fontana@unich.it
Fax: +39 0871 3554791
Tel: +39 0871 3554790

b Institute for Bioengineering and Institute for Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Station 15, Lausanne, Switzerland

Abstract

The use of the biocompatible amphiphilic diblock copolymer poly(ethylene glycol-b-propylene sulfide) (PEG44PPS20) allows a tuned loading of doxorubicin onto the surface of non-functionalized multi-walled carbon nanotubes and an efficient cell internalization. The obtained multi-walled carbon nanotube-based systems show enhanced cytotoxic activity with respect to non-vehicled doxorubicin.

Graphical abstract: Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C0NR00444H
Article type
Communication
Submitted
25 Jun 2010
Accepted
25 Nov 2010
First published
23 Dec 2010

Nanoscale, 2011,3, 925-928

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Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs

A. Di Crescenzo, D. Velluto, J. A. Hubbell and A. Fontana, Nanoscale, 2011, 3, 925 DOI: 10.1039/C0NR00444H

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