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Issue 9, 2011
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Platensimycin and its relatives: A recent story in the struggle to develop new naturally derived antibiotics

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Abstract

Covering: up to early 2010

The isolation, occurrence, structure elucidation, chemical properties, biosynthesis and chemical synthesis of the naturally occurring antibiotics platensimycin, platencin, isoplatensimycin, platensimycin A1, and platensimycin B1–B3 are described. These antibiotics attract much attention due to their novel mode of action against multidrug resistant bacterial strains. Not only the naturally occurring molecules, but also their synthetic analogues, such as carbaplatensimycin, adamantaplatensimycins, oxazinidinyl platensimycin, platencin A1, (−)-nor-platencin, homoplatensimide, and platensimide, are included in this review. Particular emphasis is placed on the diverse approaches for chemical synthesis and the recent efforts to produce potentially more effective derivatives by chemical modification or total synthesis.

Graphical abstract: Platensimycin and its relatives: A recent story in the struggle to develop new naturally derived antibiotics

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Publication details

The article was received on 06 Feb 2011 and first published on 02 Aug 2011


Article type: Review Article
DOI: 10.1039/C1NP00010A
Nat. Prod. Rep., 2011,28, 1534-1579

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    Platensimycin and its relatives: A recent story in the struggle to develop new naturally derived antibiotics

    M. Saleem, H. Hussain, I. Ahmed, T. van Ree and K. Krohn, Nat. Prod. Rep., 2011, 28, 1534
    DOI: 10.1039/C1NP00010A

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