Issue 3, 2011
From the journal:

Natural Product Reports

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

Huaming Shenga  and  Hongbin Sun*a  

* Corresponding authors

a Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, China
E-mail: hbsun2000@yahoo.com
Fax: +86 25-83271198
Tel: +86 25-83271198

Abstract

Covering: up to May 2010

This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and vascular diseases.

Graphical abstract: Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

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Article information

DOI
https://doi.org/10.1039/C0NP00059K
Article type
Review Article
Submitted
22 Oct 2010
First published
02 Feb 2011

Nat. Prod. Rep., 2011,28, 543-593

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Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

H. Sheng and H. Sun, Nat. Prod. Rep., 2011, 28, 543 DOI: 10.1039/C0NP00059K

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