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Issue 3, 2011
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Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

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Abstract

Covering: up to May 2010

This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and vascular diseases.

Graphical abstract: Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

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Article information


Submitted
22 Oct 2010
First published
02 Feb 2011

Nat. Prod. Rep., 2011,28, 543-593
Article type
Review Article

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

H. Sheng and H. Sun, Nat. Prod. Rep., 2011, 28, 543
DOI: 10.1039/C0NP00059K

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