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Issue 11, 2011
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Synthesis, colloidal stability and 64Cu labeling of iron oxide nanoparticles bearing different macrocyclic ligands

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Abstract

The synthesis, solution stability and 64Cu2+ labeling of magnetite nanoparticles (NPs) coated with different macrocycles is reported, together with the stability of the resulting radioisotope-labeled NPs to transchelation by the competing ligand cyclam, and their stability in blood serum. Three macrocycles, 1,4-bis(2-pyridylmethyl)-1,4,7-triazacyclononane (dmptacn), 1,4,8,11-tetraazacyclotetradecane (cyclam) and 1,4,7,10-tetraazacyclododecane (cyclen), and 3-aminopropyltriethoxysilane were used to modify the magnetite NPs. The ligands were covalently linked to the surface of the NPs with high efficiency by reaction of the corresponding 3-(3-(triethoxysiloxy)propoxy)propan-2-ol derivatives with the NPs. According to transmission electron microscopy (TEM), the uncoated magnetite NPs and macrocycle-functionalized congeners have an average diameter of 6 to 7 nm. The NPs form stable colloidal suspensions in 0.05 M aqueous 2-(N-morpholino)ethanesulfonic acid (MES) buffer, which consist of larger aggregates with a mean hydrodynamic size of about 200 nm. The NPs with the appended macrocycles can be efficiently labeled with 64Cu2+ ions and the radioactivity persists in rat plasma for at least 24 h. Challenge experiments with cyclam also indicate that the radiocopper complexes are highly stable, with the dmptacn-functionalized NPs showing the highest resistance to metal ion leakage. Overall, the dmptacn-functionalized iron oxide NPs provide an excellent platform for the development of robust multimodal cancer imaging/therapeutic agents.

Graphical abstract: Synthesis, colloidal stability and 64Cu labeling of iron oxide nanoparticles bearing different macrocyclic ligands

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Publication details

The article was received on 24 Jun 2011, accepted on 26 Aug 2011 and first published on 30 Sep 2011


Article type: Paper
DOI: 10.1039/C1NJ20558G
Citation: New J. Chem., 2011,35, 2705-2712

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    Synthesis, colloidal stability and 64Cu labeling of iron oxide nanoparticles bearing different macrocyclic ligands

    J. A. Barreto, M. Matterna, B. Graham, H. Stephan and L. Spiccia, New J. Chem., 2011, 35, 2705
    DOI: 10.1039/C1NJ20558G

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