Issue 3, 2011
From the journal:

New Journal of Chemistry

Bioreductive molecular probe: fluorescence signalling upon reduction of an azo group†

Manikandan Kadirvel,‡a   Nicholas J. W. Rattray,‡a   Ramkumar Rajendran,a   Waleed A. Zalloum,a   Abdul Gbaj,a   Constantinos Demonacos,a   Elena V. Bichenkova*a  and  Sally Freeman*a  

* Corresponding authors

a School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Oxford Road, Manchester, UK
E-mail: sally.freeman@manchester.ac.uk, elena.bichenkova@manchester.ac.uk

Abstract

The intramolecular heterodimer probe 4-O-dabsyl-2-O-dansyl-myo-inositol-1,3,5-orthoformate undergoes biomimetic reduction of the azo bond in the dabsyl group to give a fluorescence emission band at 560 nm. This is attributed to the loss of energy transfer between the fluorophore (dansyl) and quencher (dabsyl) groups as a result of the formation of 4-O-(4-aminobenzene sulfonyl)-2-O-dansyl-myo-inositol-1,3,5-orthoformate.

Graphical abstract: Bioreductive molecular probe: fluorescence signalling upon reduction of an azo group

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Article information

DOI
https://doi.org/10.1039/C0NJ00849D
Article type
Paper
Submitted
31 Oct 2010
Accepted
06 Dec 2010
First published
04 Jan 2011

New J. Chem., 2011,35, 701-708

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Bioreductive molecular probe: fluorescence signalling upon reduction of an azo group

M. Kadirvel, N. J. W. Rattray, R. Rajendran, W. A. Zalloum, A. Gbaj, C. Demonacos, E. V. Bichenkova and S. Freeman, New J. Chem., 2011, 35, 701 DOI: 10.1039/C0NJ00849D

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