Issue 11, 2011

Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance

Abstract

Cobalt (Co) is present in trace amounts in the environment but it can be toxic when it accumulates in cells. The question of how Co produces its toxic effects and how living organisms protect themselves from, and resist to, such a stress remains to be clarified. Studies pertaining to these issues were recently carried out in Escherichia coli and Salmonella enterica. Iron–sulfur proteins were identified as primary targets of Co ions. Perturbation of iron homeostasis, oxidative stress and possible effects on sulfur assimilation were noticed. Cells were found to respond by up-regulating genes involved in the biosynthesis of Fe–S clusters as well as genes involved in Co efflux. These data are summarized in this review article to provide a preliminary general view of Co toxicity mechanisms in these two bacterial models.

Graphical abstract: Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance

Article information

Article type
Minireview
Submitted
15 Jul 2011
Accepted
06 Sep 2011
First published
26 Sep 2011

Metallomics, 2011,3, 1130-1134

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