Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage†
Abstract
Reactions of cytotoxic platinum
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* Corresponding authors
a
Institute of Inorganic and Analytical Chemistry, Friedrich-Schiller-University Jena, Humboldstraße 8, 07743 Jena, Germany
E-mail:
wolfgang.weigand@uni-jena.de
Fax: +49 3641 948102
b Mass Spectrometry Center (CISM), University of Florence, via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy
c
Laboratory of Metals in Medicine, Department of Chemistry, University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy
E-mail:
luigi.messori@unifi.it
Fax: +39 055 4573385
Reactions of cytotoxic platinum
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