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Issue 10, 2011
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Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(II) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage

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Abstract

Reactions of cytotoxic platinum drugs with proteins are attracting growing attention for their relevant biological implications. We report here on the reactions of two cis-diphosphane platinum(II) dichlorides (namely cis-bis(trimethylphosphane) platinum(II) dichloride and cis-bis(triethylphosphane) platinum(II) dichloride) with horse heart cytochrome c (cyt c) monitored through advanced ESI MS methods coupled to enzymatic digestion. A remarkable selectivity in terms of adduct stoichiometry is highlighted and the specific metal binding sites are localised on the protein surface.

Graphical abstract: Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage

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Publication details

The article was received on 17 Jun 2011, accepted on 12 Sep 2011 and first published on 22 Sep 2011


Article type: Communication
DOI: 10.1039/C1MT00069A
Citation: Metallomics, 2011,3, 987-990

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    Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(II) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage

    C. Mügge, E. Micheucci, F. Boscaro, C. Gabbiani, L. Messori and W. Weigand, Metallomics, 2011, 3, 987
    DOI: 10.1039/C1MT00069A

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