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Issue 4, 2011
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Carrier protein substrates in cytochrome P450-catalysed oxidation

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Abstract

Enzymes of the cytochrome P450 superfamily can catalyse many types of oxidative transformations of a diverse substrate range. This review summarises recent work on an subset of P450s that accept their substrates in carrier protein-bound form. These examples show how the oxidative power and precision that P450s bring to natural products biosynthesis can be coupled with the advantages of using a carrier protein as a scaffold for oxidation.

Graphical abstract: Carrier protein substrates in cytochrome P450-catalysed oxidation

  • This article is part of the themed collection: Cytochromes
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Article information


Submitted
18 Nov 2010
Accepted
06 Jan 2011
First published
18 Jan 2011

Metallomics, 2011,3, 323-326
Article type
Minireview

Carrier protein substrates in cytochrome P450-catalysed oxidation

M. J. Cryle, Metallomics, 2011, 3, 323
DOI: 10.1039/C0MT00081G

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