Carrier        protein substrates in cytochrome P450-catalysed oxidation

Max J. Cryle

doi:10.1039/C0MT00081G

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Carrier protein substrates in cytochrome P450-catalysed oxidation†‡

Max J. Cryle*^a

Author affiliations

* Corresponding authors

^a Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
E-mail: Max.Cryle@mpimf-heidelberg.mpg.de
Fax: 49 6221 486585
Tel: 49 6221 486536

Abstract

Enzymes of the cytochrome P450 superfamily can catalyse many types of oxidative transformations of a diverse substrate range. This review summarises recent work on an subset of P450s that accept their substrates in carrier protein-bound form. These examples show how the oxidative power and precision that P450s bring to natural products biosynthesis can be coupled with the advantages of using a carrier protein as a scaffold for oxidation.