Issue 9, 2011
From the journal:

MedChemComm

Design and syntheses of some iminosugar derivatives as potential immunosuppressants†

Guo-Liang Zhang,a   Xiu-Jing Zheng,a   Li-He Zhanga  and  Xin-Shan Ye*a  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, Peking University, and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing, China
E-mail: xinshan@bjmu.edu.cn
Fax: +86 10 82802724
Tel: +86 10 82805736

Abstract

Eleven new iminosugar derivatives were synthesized and the effects of these synthetic iminosugars on proliferation of the mouse splenocytes were evaluated by the cell counting kit-8 (CCK-8) assay. The preliminary structure–activity relationships were deduced from the experimental data. It was found that iminosugar 14 (IC50 = 22 μM) and its C-5 epimer 15 (IC50 = 45 μM) displayed the strongest inhibitory effects, and might hold potential as immunosuppressive agents.

Graphical abstract: Design and syntheses of some iminosugar derivatives as potential immunosuppressants

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Article information

DOI
https://doi.org/10.1039/C1MD00098E
Article type
Concise Article
Submitted
08 Apr 2011
Accepted
10 Jun 2011
First published
08 Jul 2011

Med. Chem. Commun., 2011,2, 909-917

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Design and syntheses of some iminosugar derivatives as potential immunosuppressants

G. Zhang, X. Zheng, L. Zhang and X. Ye, Med. Chem. Commun., 2011, 2, 909 DOI: 10.1039/C1MD00098E

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