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Issue 10, 2011
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Are pyridazines privileged structures?

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Abstract

One can estimate that about 50% of all the drug molecules used in medicine contain a phenyl ring which can be substituted or not. The bioisosteric replacement of these phenyl rings by the corresponding pyridazine rings opens an access to several thousands of diaza analogues presenting more interaction possibilities, lower Log P values and improved crystalline salts. The use of pyridazine scaffolds in place of phenyl scaffolds entails additional interaction possibilities. Another interest of pyridazines is their capacity to act as original functional surrogates. Thus, aminopyridazines can be used as carboxamide, as well as amine surrogates. Finally, the many examples of pyridazines used either as a structural element or as a main scaffold, justify largely their status as privileged structures

Graphical abstract: Are pyridazines privileged structures?

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Article information


Submitted
15 Mar 2011
Accepted
17 Apr 2011
First published
10 Jun 2011

Med. Chem. Commun., 2011,2, 935-941
Article type
Review Article

Are pyridazines privileged structures?

C. G. Wermuth, Med. Chem. Commun., 2011, 2, 935
DOI: 10.1039/C1MD00074H

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