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Issue 4, 2011
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New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

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Abstract

The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.

Graphical abstract: New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

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Publication details

The article was received on 19 Nov 2010, accepted on 16 Jan 2011 and first published on 11 Feb 2011


Article type: Concise Article
DOI: 10.1039/C0MD00230E
Citation: Med. Chem. Commun., 2011,2, 278-282

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    New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

    O. Yoshida, J. Nakamura, H. Yamashiro, K. Miura, S. Hayashi, K. Umetsu, S. Xu, H. Maki and H. Arimoto, Med. Chem. Commun., 2011, 2, 278
    DOI: 10.1039/C0MD00230E

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