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Issue 11, 2011
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Novel thalidomide analogues with potent NFκB and TNF expression inhibition

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Abstract

A series of N-phenyl thalidomide analogues have been prepared efficiently through a Buchwald–Hartwig cross coupling reaction as the key step. Several of these compounds have extraordinary TNF expression inhibition compared to both thalidomide and the current pharmaceutical agent Revlimid (Lenalidomide).

Graphical abstract: Novel thalidomide analogues with potent NFκB and TNF expression inhibition

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Publication details

The article was received on 19 Jul 2011, accepted on 15 Aug 2011 and first published on 07 Sep 2011


Article type: Concise Article
DOI: 10.1039/C1MD00184A
Citation: Med. Chem. Commun., 2011,2, 1073-1078
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    Novel thalidomide analogues with potent NFκB and TNF expression inhibition

    S. Y. Yeung, S. Kampmann, K. A. Stubbs, B. W. Skelton, B. J. Kaskow, L. J. Abraham and S. G. Stewart, Med. Chem. Commun., 2011, 2, 1073
    DOI: 10.1039/C1MD00184A

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