Issue 11, 2011
From the journal:

MedChemComm

Novel thalidomide analogues with potent NFκB and TNF expression inhibition†‡

Sing Yee Yeung,a   Sven Kampmann,a   Keith A. Stubbs,a   Brian W. Skelton,b   Belinda J. Kaskow,a   Lawrence J. Abrahama  and  Scott G. Stewart*a  

* Corresponding authors

a The School of Biomedical, Biomolecular & Chemical Sciences, The University of Western Australia, Crawley, WA, Australia
E-mail: sgs@cyllene.uwa.edu.au
Fax: +61 (8) 6488 1005
Tel: +61 (8) 6488 3180

b Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, WA, Australia

Abstract

A series of N-phenyl thalidomide analogues have been prepared efficiently through a Buchwald–Hartwig cross coupling reaction as the key step. Several of these compounds have extraordinary TNF expression inhibition compared to both thalidomide and the current pharmaceutical agent Revlimid (Lenalidomide).

Graphical abstract: Novel thalidomide analogues with potent NFκB and TNF expression inhibition

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Article information

DOI
https://doi.org/10.1039/C1MD00184A
Article type
Concise Article
Submitted
19 Jul 2011
Accepted
15 Aug 2011
First published
07 Sep 2011

Med. Chem. Commun., 2011,2, 1073-1078

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Novel thalidomide analogues with potent NFκB and TNF expression inhibition

S. Y. Yeung, S. Kampmann, K. A. Stubbs, B. W. Skelton, B. J. Kaskow, L. J. Abraham and S. G. Stewart, Med. Chem. Commun., 2011, 2, 1073 DOI: 10.1039/C1MD00184A

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