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Issue 11, 2011
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Novel thalidomide analogues with potent NFκB and TNF expression inhibition

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Abstract

A series of N-phenyl thalidomide analogues have been prepared efficiently through a Buchwald–Hartwig cross coupling reaction as the key step. Several of these compounds have extraordinary TNF expression inhibition compared to both thalidomide and the current pharmaceutical agent Revlimid (Lenalidomide).

Graphical abstract: Novel thalidomide analogues with potent NFκB and TNF expression inhibition

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Supplementary files

Article information


Submitted
19 Jul 2011
Accepted
15 Aug 2011
First published
07 Sep 2011

Med. Chem. Commun., 2011,2, 1073-1078
Article type
Concise Article

Novel thalidomide analogues with potent NFκB and TNF expression inhibition

S. Y. Yeung, S. Kampmann, K. A. Stubbs, B. W. Skelton, B. J. Kaskow, L. J. Abraham and S. G. Stewart, Med. Chem. Commun., 2011, 2, 1073
DOI: 10.1039/C1MD00184A

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