Issue 10, 2011

A pseudorotaxane umbrella thread with chloride transmembrane transport properties

Abstract

We present here the synthesis and the transmembrane transport properties of a cholic acid-functionalized pseudorotaxane thread. The anion transport properties of this amphiphilic thread can be changed by the assembly of a [2]-pseudorotaxane. Besides its interest and potential application as chloride transmembrane transporter, the amphiphilic properties of the umbrella thread presented here may be of interest to transport cyclic drugs across the cell membrane.

Graphical abstract: A pseudorotaxane umbrella thread with chloride transmembrane transport properties

Supplementary files

Article information

Article type
Concise Article
Submitted
17 May 2011
Accepted
26 Jul 2011
First published
19 Aug 2011

Med. Chem. Commun., 2011,2, 987-990

A pseudorotaxane umbrella thread with chloride transmembrane transport properties

C. Chhun and A. R. Schmitzer, Med. Chem. Commun., 2011, 2, 987 DOI: 10.1039/C1MD00128K

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