Issue 11, 2011
From the journal:

MedChemComm

Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents†

Yu Luo,‡a   Feng Xiao,‡a   Shijing Qian,c   Qiaojun He,c   Wei Lu*ab  and  Bo Yang*c  

* Corresponding authors

a Department of Chemistry, East China Normal University, Shanghai, China

b Institute of Drug Discovery and Development, iAIR, East China Normal University, Shanghai, China
E-mail: wlu@chem.ecnu.edu.cn
Fax: +86(21)62602475
Tel: +86(21)62602475

c College of Pharmaceutical Science, Zhejiang University, Hangzhou, China
E-mail: yang924@zju.edu.cn
Fax: +86(571)88208400
Tel: +86(571)88208400

Abstract

A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

Graphical abstract: Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

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Article information

DOI
https://doi.org/10.1039/C1MD00105A
Article type
Concise Article
Submitted
20 Apr 2011
Accepted
06 Aug 2011
First published
07 Sep 2011

Med. Chem. Commun., 2011,2, 1054-1057

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Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

Y. Luo, F. Xiao, S. Qian, Q. He, W. Lu and B. Yang, Med. Chem. Commun., 2011, 2, 1054 DOI: 10.1039/C1MD00105A

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