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Issue 8, 2011
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Do proteinprotein interaction databases identify moonlighting proteins?

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One of the most striking results of the human (and mammalian) genomes is the low number of protein-coding genes. To-date, the main molecular mechanism to increase the number of different protein isoforms and functions is alternative splicing. However, a less-known way to increase the number of protein functions is the existence of multifunctional, multitask, or “moonlighting”, proteins. By and large, moonlighting proteins are experimentally disclosed by serendipity. Proteomics is becoming one of the very active areas of biomedical research, which permits researchers to identify previously unseen connections among proteins and pathways. In principle, proteinprotein interaction (PPI) databases should contain information on moonlighting proteins and could provide suggestions to further analysis in order to prove the multifunctionality. As far as we know, nobody has verified whether PPI databases actually disclose moonlighting proteins. In the present work we check whether well-established moonlighting proteins present in PPI databases connect with their known partners and, therefore, a careful inspection of these databases could help to suggest their different functions. The results of our research suggest that PPI databases could be a valuable tool to suggest multifunctionality.

Graphical abstract: Do protein–protein interaction databases identify moonlighting proteins?

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The article was received on 12 May 2011, accepted on 31 May 2011 and first published on 16 Jun 2011

Article type: Communication
DOI: 10.1039/C1MB05180F
Citation: Mol. BioSyst., 2011,7, 2379-2382
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    Do proteinprotein interaction databases identify moonlighting proteins?

    A. Gómez, S. Hernández, I. Amela, J. Piñol, J. Cedano and E. Querol, Mol. BioSyst., 2011, 7, 2379
    DOI: 10.1039/C1MB05180F

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