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Issue 4, 2011
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A metabolomics strategy for detecting protein–metabolite interactions to identify natural nuclear receptor ligands

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Abstract

Nuclear receptors are ligand-regulated transcription factors that control a range of (patho)physiological processes. Lipids are the most common type of nuclear receptor ligands. Here, we utilize a metabolomics approach that detects protein–metabolite interactions to identify endogenous peroxisome proliferator-activated receptor (PPAR) ligands from tissue and cell extracts.

Graphical abstract: A metabolomics strategy for detecting protein–metabolite interactions to identify natural nuclear receptor ligands

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Supplementary files

Article information


Submitted
11 Dec 2010
Accepted
18 Jan 2011
First published
31 Jan 2011

Mol. BioSyst., 2011,7, 1046-1049
Article type
Communication

A metabolomics strategy for detecting protein–metabolite interactions to identify natural nuclear receptor ligands

Y. Kim, A. C. Lou and A. Saghatelian, Mol. BioSyst., 2011, 7, 1046
DOI: 10.1039/C0MB00324G

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