Jump to main content
Jump to site search

Issue 3, 2011
Previous Article Next Article

The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

Author affiliations

Abstract

Using evolved pyrrolysyl-tRNA synthetase–tRNAPylCUA pairs, L-phenylalanine, p-iodo-L-phenylalanine and p-bromo-L-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.

Graphical abstract: The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Sep 2010, accepted on 16 Dec 2010 and first published on 14 Jan 2011


Article type: Communication
DOI: 10.1039/C0MB00217H
Mol. BioSyst., 2011,7, 714-717

  •   Request permissions

    The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives

    Y. Wang, W. K. Russell, Z. Wang, W. Wan, L. E. Dodd, P. Pai, D. H. Russell and W. R. Liu, Mol. BioSyst., 2011, 7, 714
    DOI: 10.1039/C0MB00217H

Search articles by author

Spotlight

Advertisements